显微修复手部周围神经后应用透明質烷胶的临床评估

Clinical evaluation of a hyaluronan-based gel following microsurgical reconstruction of peripheral nerves of the hand

Atzei A, Calcagni M, Breda B, Fasolo G, Pajardi G, Cugola L.
Hand Surgery Unit, Policlinico G.B. Rossi, Azienda Ospedaliera-Universitaria, Verona, Italy. andrea.atze@univr.it

A controlled clinical trial was performed to investigate the safety and efficacy of the hyaluronate-based gel polymer Hyaloglide after microsurgical reconstruction of peripheral nerves of the hand. Thirty patients were randomized to receive either no postsurgical treatment (n = 16) or Hyaloglide (n = 14) and were clinically evaluated at various intervals for 1 year. The application of Hyaloglide posed no safety concerns. Efficacy was assessed by the recovery of sensitivity, measurement of pain, and progression of Tinel's sign. The Hyaloglide-treated group showed better improvement in recovery from pain, approaching statistical significance during the first 3 months postsurgery. Likewise, recovery of sensitivity was also higher in the Hyaloglide-treated group throughout the entire follow-up period, and the distance of Tinel's sign was longer in the Hyaloglide-treated group (P < 0.05 at day 30). The application of Hyaloglide may improve recovery of sensitivity and decrease pain following microsurgical repair of the peripheral nerves of the hand. (c) 2007 Wiley-Liss, Inc.

PMID: 17205576 [PubMed - indexed for MEDLINE]